8bw8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex== | |
| - | + | <StructureSection load='8bw8' size='340' side='right'caption='[[8bw8]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bw8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BW8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bw8 OCA], [https://pdbe.org/8bw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bw8 RCSB], [https://www.ebi.ac.uk/pdbsum/8bw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bw8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AVE_DROME AVE_DROME] Required for normal photoreceptor differentiation between Ras and Raf for EGFR signaling in the eye and for mitogen-activated protein kinase phosphorylation. Probably acts together with Cnk to promote Raf activation, perhaps by recruiting an activating kinase. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Drosophila melanogaster]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kurinov I]] | ||
| + | [[Category: Maisonneuve P]] | ||
| + | [[Category: Sicheri F]] | ||
Revision as of 08:52, 21 February 2024
Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex
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