8ch8

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m (Protected "8ch8" [edit=sysop:move=sysop])
Current revision (08:53, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ch8 is ON HOLD until Paper Publication
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==Crystal structure of the human PXR ligand-binding domain in complex with liranaftate==
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<StructureSection load='8ch8' size='340' side='right'caption='[[8ch8]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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Authors: Carivenc, C., Derosa, Q., Grimaldi, M., Boulahtouf, A., Balaguer, P., Bourguet, W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ch8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CH8 FirstGlance]. <br>
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Description: Crystal structure of the human PXR ligand-binding domain in complex with liranaftate
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ULC:~{O}-(5,6,7,8-tetrahydronaphthalen-2-yl)+~{N}-(6-methoxypyridin-2-yl)-~{N}-methyl-carbamothioate'>ULC</scene></td></tr>
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[[Category: Derosa, Q]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ch8 OCA], [https://pdbe.org/8ch8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ch8 RCSB], [https://www.ebi.ac.uk/pdbsum/8ch8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ch8 ProSAT]</span></td></tr>
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[[Category: Balaguer, P]]
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</table>
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[[Category: Carivenc, C]]
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== Function ==
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[[Category: Boulahtouf, A]]
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[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
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[[Category: Grimaldi, M]]
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== References ==
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[[Category: Bourguet, W]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Balaguer P]]
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[[Category: Boulahtouf A]]
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[[Category: Bourguet W]]
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[[Category: Carivenc C]]
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[[Category: Derosa Q]]
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[[Category: Grimaldi M]]

Current revision

Crystal structure of the human PXR ligand-binding domain in complex with liranaftate

PDB ID 8ch8

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