8rij

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'''Unreleased structure'''
 
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The entry 8rij is ON HOLD until Paper Publication
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==Discovery of the first orally bioavailable ADAMTS7 inhibitor BAY-9835==
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<StructureSection load='8rij' size='340' side='right'caption='[[8rij]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8rij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RIJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H07:~{N}-[[(4~{R})-4-cyclopropyl-2,5-bis(oxidanylidene)imidazolidin-4-yl]methyl]-2-(3-fluorophenyl)-1,2,3-triazole-4-carboxamide'>A1H07</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rij OCA], [https://pdbe.org/8rij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rij RCSB], [https://www.ebi.ac.uk/pdbsum/8rij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rij ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Beyer K]]
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[[Category: Broehl A]]
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[[Category: Cancho-Grande Y]]
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[[Category: Elowe N]]
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[[Category: Henninger K]]
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[[Category: Johannes S]]
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[[Category: Jungmann N]]
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[[Category: Krainz T]]
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[[Category: Lindner N]]
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[[Category: Maassen S]]
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[[Category: MacDonald B]]
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[[Category: Meibom D]]
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[[Category: Menshykau D]]
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[[Category: Mittendorf J]]
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[[Category: Sanchez G]]
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[[Category: Schafer M]]
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[[Category: Stefan E]]
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[[Category: Torge A]]
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[[Category: Wasnaire P]]
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[[Category: Xing Y]]
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[[Category: Zubov D]]

Revision as of 08:57, 21 February 2024

Discovery of the first orally bioavailable ADAMTS7 inhibitor BAY-9835

PDB ID 8rij

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OCA

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