8smv
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==GPR161 Gs heterotrimer== | |
| - | + | <StructureSection load='8smv' size='340' side='right'caption='[[8smv]], [[Resolution|resolution]] 2.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8smv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SMV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.74Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8smv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8smv OCA], [https://pdbe.org/8smv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8smv RCSB], [https://www.ebi.ac.uk/pdbsum/8smv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8smv ProSAT]</span></td></tr> |
| - | [[Category: Harrison | + | </table> |
| - | [[Category: Hoppe | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/GP161_HUMAN GP161_HUMAN] Pituitary stalk interruption syndrome. Disease susceptibility may be associated with variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GP161_HUMAN GP161_HUMAN] Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Lama glama]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Harrison S]] | ||
| + | [[Category: Hoppe N]] | ||
| + | [[Category: Manglik A]] | ||
Revision as of 08:58, 21 February 2024
GPR161 Gs heterotrimer
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