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1qdn

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[[Image:1qdn.jpg|left|200px]]
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{{Structure
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02359 CDC48_N], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02933 CDC48_2]</span>
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{{STRUCTURE_1qdn| PDB=1qdn | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdn OCA], [http://www.ebi.ac.uk/pdbsum/1qdn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qdn RCSB]</span>
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'''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''
'''AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)'''
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[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: Whiteheart, S W.]]
[[Category: Whiteheart, S W.]]
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[[Category: double-psi beta barrel alpha/beta barrel]]
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[[Category: Double-psi beta barrel alpha/beta barrel]]
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[[Category: vesicular-fusion protein]]
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[[Category: Vesicular-fusion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:09:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:21 2008''
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Revision as of 03:09, 3 May 2008

Image:1qdn.jpg

Template:STRUCTURE 1qdn

AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)


Overview

The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein alpha-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with respect to one another during the catalytic cycle of NSF. Structure-based sequence alignments indicate that in addition to NSF orthologues, the p97 family of ATPases contain an amino-terminal domain of similar structure.

About this Structure

1QDN is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein., May AP, Misura KM, Whiteheart SW, Weis WI, Nat Cell Biol. 1999 Jul;1(3):175-82. PMID:10559905 Page seeded by OCA on Sat May 3 06:09:56 2008

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