2qwy
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [https://pdbe.org/2qwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [https://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [https://pdbe.org/2qwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [https://www.ebi.ac.uk/pdbsum/2qwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qwy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | In bacteria, numerous genes harbor regulatory elements in the 5' untranslated regions of their mRNA, termed riboswitches, which control gene expression by binding small-molecule metabolites. These sequences influence the secondary and tertiary structure of the RNA in a ligand-dependent manner, thereby directing its transcription or translation. The crystal structure of an S-adenosylmethionine-responsive riboswitch found predominantly in proteobacteria, SAM-II, has been solved to reveal a second means by which RNA interacts with this important cellular metabolite. Notably, this is the first structure of a complete riboswitch containing all sequences associated with both the ligand binding aptamer domain and the regulatory expression platform. Chemical probing of this RNA in the absence and presence of ligand shows how the structure changes in response to S-adenosylmethionine to sequester the ribosomal binding site and affect translational gene regulation. | ||
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| - | Structure of the SAM-II riboswitch bound to S-adenosylmethionine.,Gilbert SD, Rambo RP, Van Tyne D, Batey RT Nat Struct Mol Biol. 2008 Feb;15(2):177-82. Epub 2008 Jan 20. PMID:18204466<ref>PMID:18204466</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2qwy" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Riboswitch 3D structures|Riboswitch 3D structures]] | *[[Riboswitch 3D structures|Riboswitch 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
SAM-II riboswitch bound to S-adenosylmethionine
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