2r0q
From Proteopedia
(Difference between revisions)
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<StructureSection load='2r0q' size='340' side='right'caption='[[2r0q]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='2r0q' size='340' side='right'caption='[[2r0q]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2r0q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2r0q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R0Q FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0q OCA], [https://pdbe.org/2r0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0q RCSB], [https://www.ebi.ac.uk/pdbsum/2r0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0q ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0q OCA], [https://pdbe.org/2r0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0q RCSB], [https://www.ebi.ac.uk/pdbsum/2r0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/BIN3_STAAU BIN3_STAAU] Potential DNA invertase. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r0q ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r0q ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | An essential feature of many site-specific recombination systems is their ability to regulate the direction and topology of recombination. Resolvases from the serine recombinase family assemble an interwound synaptic complex that harnesses negative supercoiling to drive the forward reaction and promote recombination between properly oriented sites. To better understand the interplay of catalytic and regulatory functions within these synaptic complexes, we have solved the structure of the regulatory site synapse in the Sin resolvase system. It reveals an unexpected synaptic interface between helix-turn-helix DNA-binding domains that is also highlighted in a screen for synapsis mutants. The tetramer defined by this interface provides the foundation for a robust model of the synaptic complex, assembled entirely from available crystal structures, that gives insight into how the catalytic activity of Sin and other serine recombinases may be regulated. | ||
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| - | Architecture of a serine recombinase-DNA regulatory complex.,Mouw KW, Rowland SJ, Gajjar MM, Boocock MR, Stark WM, Rice PA Mol Cell. 2008 Apr 25;30(2):145-55. PMID:18439894<ref>PMID:18439894</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2r0q" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Resolvase 3D structures|Resolvase 3D structures]] | *[[Resolvase 3D structures|Resolvase 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Staphylococcus aureus]] |
| - | [[Category: | + | [[Category: Mouw KW]] |
| - | [[Category: | + | [[Category: Rice PA]] |
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Current revision
Crystal structure of a serine recombinase- DNA regulatory complex
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