1qfc

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[[Image:1qfc.jpg|left|200px]]
[[Image:1qfc.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1qfc |SIZE=350|CAPTION= <scene name='initialview01'>1qfc</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1qfc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1qfc| PDB=1qfc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qfc OCA], [http://www.ebi.ac.uk/pdbsum/1qfc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qfc RCSB]</span>
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}}
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'''STRUCTURE OF RAT PURPLE ACID PHOSPHATASE'''
'''STRUCTURE OF RAT PURPLE ACID PHOSPHATASE'''
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[[Category: Svensson, C.]]
[[Category: Svensson, C.]]
[[Category: Uppenberg, J.]]
[[Category: Uppenberg, J.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: metal phosphatase]]
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[[Category: Metal phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:11:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:40 2008''
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Revision as of 03:11, 3 May 2008

Image:1qfc.jpg

Template:STRUCTURE 1qfc

STRUCTURE OF RAT PURPLE ACID PHOSPHATASE


Overview

Tartrate-resistant acid phosphatase (TRAP) is a mammalian di-iron- containing enzyme that belongs to the family of purple acid phosphatases (PAP). It is highly expressed in a limited number of tissues, predominantly in bone-resorbing osteoclasts and in macrophages of spleen. We have determined the crystal structure of rat TRAP in complex with a phosphate ion to 2.7 A resolution. The fold resembles that of the catalytic domain of kidney bean purple acid phosphatase (KBPAP), although the sequence similarity is limited to the active site residues. A surface loop near the active site is absent due to proteolysis, leaving the active-site easily accessible from the surrounding solvent. This, we believe, gives a structural explanation for the observed proteolytic activation of TRAP. The current structure was determined at a relatively high pH and without any external reducing agents. It is likely that it represents an oxidized and therefore catalytically inactive form of the enzyme.

About this Structure

1QFC is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a mammalian purple acid phosphatase., Uppenberg J, Lindqvist F, Svensson C, Ek-Rylander B, Andersson G, J Mol Biol. 1999 Jul 2;290(1):201-11. PMID:10388567 Page seeded by OCA on Sat May 3 06:11:58 2008

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