3b8j
From Proteopedia
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<StructureSection load='3b8j' size='340' side='right'caption='[[3b8j]], [[Resolution|resolution]] 2.51Å' scene=''> | <StructureSection load='3b8j' size='340' side='right'caption='[[3b8j]], [[Resolution|resolution]] 2.51Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3b8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3b8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B8J FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.507Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8j OCA], [https://pdbe.org/3b8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b8j RCSB], [https://www.ebi.ac.uk/pdbsum/3b8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b8j ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8j OCA], [https://pdbe.org/3b8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b8j RCSB], [https://www.ebi.ac.uk/pdbsum/3b8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b8j ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DEGS_ECOLI DEGS_ECOLI] When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMPs) and then initiates RseA (anti sigma-E factor) degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by RseP. This cascade that ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly.<ref>PMID:12183369</ref> <ref>PMID:19695325</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Escherichia coli]] | + | [[Category: Escherichia coli K-12]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Grant | + | [[Category: Grant RA]] |
| - | [[Category: Sauer | + | [[Category: Sauer RT]] |
| - | [[Category: Sohn | + | [[Category: Sohn J]] |
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Current revision
Q191A mutant of DegS-deltaPDZ
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