1qft

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[[Image:1qft.gif|left|200px]]
[[Image:1qft.gif|left|200px]]
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{{Structure
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|PDB= 1qft |SIZE=350|CAPTION= <scene name='initialview01'>1qft</scene>, resolution 1.25&Aring;
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The line below this paragraph, containing "STRUCTURE_1qft", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>
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{{STRUCTURE_1qft| PDB=1qft | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qft OCA], [http://www.ebi.ac.uk/pdbsum/1qft PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qft RCSB]</span>
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'''HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS'''
'''HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS'''
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[[Category: Paesen, G C.]]
[[Category: Paesen, G C.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: lipocalin]]
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[[Category: Lipocalin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:13:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:55 2008''
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Revision as of 03:13, 3 May 2008

Image:1qft.gif

Template:STRUCTURE 1qft

HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS


Overview

High-affinity histamine-binding proteins (HBPs) were discovered in the saliva of Rhipicephalus appendiculatus ticks. Their ability to outcompete histamine receptors indicates that they suppress inflammation during blood feeding. The crystal structure of a histamine-bound HBP, determined at 1.25 A resolution, reveals a lipocalin fold novel in containing two binding sites for the same ligand. The sites are orthogonally arranged and highly rigid and form an internal surface of unusual polar character that complements the physicochemical properties of histamine. As soluble receptors of histamine, HBPs offer a new strategy for controlling histamine-based diseases.

About this Structure

1QFT is a Single protein structure of sequence from Rhipicephalus appendiculatus. Full crystallographic information is available from OCA.

Reference

Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure., Paesen GC, Adams PL, Harlos K, Nuttall PA, Stuart DI, Mol Cell. 1999 May;3(5):661-71. PMID:10360182 Page seeded by OCA on Sat May 3 06:13:03 2008

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