3hsc

<table><tr><td colspan='2'>[[3hsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hsc 2hsc] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hsc 1hsc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3HSC FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsc OCA], [http://pdbe.org/3hsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hsc RCSB], [http://www.ebi.ac.uk/pdbsum/3hsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsc ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).

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== Publication Abstract from PubMed ==

The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein.,Flaherty KM, DeLuca-Flaherty C, McKay DB Nature. 1990 Aug 16;346(6285):623-8. PMID:2143562<ref>PMID:2143562</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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*[[Non-polymerizable monomeric actin|Non-polymerizable monomeric actin]]

== References ==

<references/>

[[Category: Adenosinetriphosphatase]]

[[Category: Bovin]]

[[Category: Deluca-Flaherty, C R]]

[[Category: Flaherty, K M]]

[[Category: Mckay, D B]]