3iby
From Proteopedia
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<StructureSection load='3iby' size='340' side='right'caption='[[3iby]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3iby' size='340' side='right'caption='[[3iby]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3iby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3iby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IBY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iby OCA], [https://pdbe.org/3iby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iby RCSB], [https://www.ebi.ac.uk/pdbsum/3iby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iby ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iby OCA], [https://pdbe.org/3iby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iby RCSB], [https://www.ebi.ac.uk/pdbsum/3iby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iby ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FEOB_LEGPN FEOB_LEGPN] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iby ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iby ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Prokaryotic pathogens have developed specialized mechanisms for efficient uptake of ferrous iron (Fe(2+)) from the host. In Legionella pneumophila, the causative agent of Legionnaires' disease, the transmembrane GTPase FeoB plays a key role in Fe(2+) acquisition and virulence. FeoB consists of a membrane-embedded core and an N-terminal, cytosolic region (NFeoB). Here, we report the crystal structure of NFeoB from L. pneumophila, revealing a monomeric protein comprising two separate domains with GTPase and guanine-nucleotide dissociation inhibitor (GDI) functions. The GDI domain displays a novel fold, whereas the overall structure of the GTPase domain resembles that of known G domains but is in the rarely observed nucleotide-free state. | ||
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| - | Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophila.,Petermann N, Hansen G, Schmidt CL, Hilgenfeld R FEBS Lett. 2010 Feb 19;584(4):733-8. Epub 2009 Dec 27. PMID:20036663<ref>PMID:20036663</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 3iby" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Atcc 33152]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Legionella pneumophila]] |
| - | + | [[Category: Hansen G]] | |
| - | + | [[Category: Hilgenfeld R]] | |
| - | + | [[Category: Petermann N]] | |
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| - | [[Category: G | + | |
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Current revision
Structure of cytosolic domain of L. pneumophila FeoB
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