3ihy

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Current revision (10:05, 21 February 2024) (edit) (undo)
 
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<StructureSection load='3ihy' size='340' side='right'caption='[[3ihy]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3ihy' size='340' side='right'caption='[[3ihy]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHY FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3C3, PIK3C3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [https://pdbe.org/3ihy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [https://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [https://pdbe.org/3ihy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [https://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
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[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phosphatidylinositol 3-kinase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Berglund H]]
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[[Category: Berg, S Van Den]]
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[[Category: Bountra C]]
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[[Category: Berglund, H]]
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[[Category: Collins R]]
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[[Category: Bountra, C]]
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[[Category: Edwards AM]]
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[[Category: Collins, R]]
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[[Category: Flodin S]]
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[[Category: Edwards, A M]]
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[[Category: Flores A]]
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[[Category: Flodin, S]]
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[[Category: Graslund S]]
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[[Category: Flores, A]]
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[[Category: Hammarstrom M]]
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[[Category: Graslund, S]]
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[[Category: Johansson A]]
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[[Category: Hammarstrom, M]]
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[[Category: Johansson I]]
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[[Category: Johansson, A]]
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[[Category: Karlberg T]]
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[[Category: Johansson, I]]
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[[Category: Kotenyova T]]
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[[Category: Karlberg, T]]
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[[Category: Kotzsch A]]
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[[Category: Kotenyova, T]]
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[[Category: Kragh Nielsen T]]
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[[Category: Kotzsch, A]]
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[[Category: Moche M]]
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[[Category: Moche, M]]
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[[Category: Nordlund P]]
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[[Category: Nielsen, T Kragh]]
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[[Category: Nyman T]]
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[[Category: Nordlund, P]]
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[[Category: Persson C]]
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[[Category: Nyman, T]]
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[[Category: Roos AK]]
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[[Category: Persson, C]]
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[[Category: Sagemark J]]
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[[Category: Roos, A K]]
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[[Category: Schueler H]]
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[[Category: Structural genomic]]
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[[Category: Schutz P]]
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[[Category: Sagemark, J]]
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[[Category: Siponen MI]]
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[[Category: Schueler, H]]
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[[Category: Thorsell AG]]
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[[Category: Schutz, P]]
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[[Category: Tresaugues L]]
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[[Category: Siponen, M I]]
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[[Category: Van Den Berg S]]
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[[Category: Thorsell, A G]]
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[[Category: Weigelt J]]
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[[Category: Tresaugues, L]]
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[[Category: Welin M]]
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[[Category: Weigelt, J]]
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[[Category: Wisniewska M]]
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[[Category: Welin, M]]
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[[Category: Wisniewska, M]]
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[[Category: Alpha/beta protein]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Manganese]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Sgc stockholm]]
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[[Category: Transferase]]
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Current revision

Human PIK3C3 crystal structure

PDB ID 3ihy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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