3iu2

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Current revision (10:06, 21 February 2024) (edit) (undo)
 
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<StructureSection load='3iu2' size='340' side='right'caption='[[3iu2]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
<StructureSection load='3iu2' size='340' side='right'caption='[[3iu2]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3iu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IU2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3iu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IU2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=096:(2R)-2-{4-HYDROXY-5-METHOXY-2-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]PHENYL}-3-PYRIDIN-3-YL-1,3-THIAZOLIDIN-4-ONE'>096</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rxt|1rxt]], [[3iu1|3iu1]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=096:(2R)-2-{4-HYDROXY-5-METHOXY-2-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]PHENYL}-3-PYRIDIN-3-YL-1,3-THIAZOLIDIN-4-ONE'>096</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMT, NMT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu2 OCA], [https://pdbe.org/3iu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iu2 RCSB], [https://www.ebi.ac.uk/pdbsum/3iu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu2 OCA], [https://pdbe.org/3iu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iu2 RCSB], [https://www.ebi.ac.uk/pdbsum/3iu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
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[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Brand, S Y]]
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[[Category: Brand SY]]
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[[Category: Cossar, D]]
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[[Category: Cossar D]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Ferguson, M A.J]]
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[[Category: Ferguson MAJ]]
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[[Category: Frearson, J A]]
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[[Category: Frearson JA]]
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[[Category: Hui, R]]
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[[Category: Hui R]]
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[[Category: Hutchinson, A]]
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[[Category: Hutchinson A]]
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[[Category: Kania, A]]
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[[Category: Kania A]]
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[[Category: Kozieradzki, I]]
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[[Category: Kozieradzki I]]
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[[Category: Lin, Y H]]
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[[Category: Lin Y-H]]
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[[Category: Qiu, W]]
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[[Category: Qiu W]]
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[[Category: Ravichandran, M]]
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[[Category: Ravichandran M]]
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[[Category: Robinson, D A]]
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[[Category: Robinson DA]]
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[[Category: Structural genomic]]
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[[Category: Schapira M]]
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[[Category: Schapira, M]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Wernimont A]]
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[[Category: Wernimont, A]]
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[[Category: Wyatt PG]]
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[[Category: Wyatt, P G]]
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[[Category: Acyltransfera]]
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[[Category: Acyltransferase]]
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[[Category: N-myristoyltransferase]]
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[[Category: Nmt1]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096

PDB ID 3iu2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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