3kln

<StructureSection load='3kln' size='340' side='right' caption='[[3kln]], [[Resolution|resolution]] 3.08&Aring;' scene=''>

<table><tr><td colspan='2'>[[3kln]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/'vibrio_eltor' 'vibrio eltor']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLN FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3klo|3klo]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VCA0952, VC_A0952 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=686 'Vibrio eltor'])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kln OCA], [http://pdbe.org/3kln PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kln RCSB], [http://www.ebi.ac.uk/pdbsum/3kln PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kln ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Microorganisms can switch from a planktonic, free-swimming life-style to a sessile, colonial state, called a biofilm, which confers resistance to environmental stress. Conversion between the motile and biofilm life-styles has been attributed to increased levels of the prokaryotic second messenger cyclic di-guanosine monophosphate (c-di-GMP), yet the signaling mechanisms mediating such a global switch are poorly understood. Here we show that the transcriptional regulator VpsT from Vibrio cholerae directly senses c-di-GMP to inversely control extracellular matrix production and motility, which identifies VpsT as a master regulator for biofilm formation. Rather than being regulated by phosphorylation, VpsT undergoes a change in oligomerization on c-di-GMP binding.

Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP.,Krasteva PV, Fong JC, Shikuma NJ, Beyhan S, Navarro MV, Yildiz FH, Sondermann H Science. 2010 Feb 12;327(5967):866-8. PMID:20150502<ref>PMID:20150502</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3kln" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Vibrio eltor]]

[[Category: Krasteva, P V]]

[[Category: Navarro, V A.S]]

[[Category: Sondermann, H]]

[[Category: Dna-binding]]

[[Category: Transcription regulation]]