3lpz

<table><tr><td colspan='2'>[[3lpz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LPZ FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iqw|3iqw]], [[3iqx|3iqx]], [[2wpv|2wpv]], [[3lku|3lku]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0028730 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lpz OCA], [http://pdbe.org/3lpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lpz RCSB], [http://www.ebi.ac.uk/pdbsum/3lpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lpz ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Tail-anchored proteins play important roles in protein translocation, membrane fusion and apoptosis. They are targeted to the endoplasmic reticulum membrane via the guided-entry of tail-anchored proteins (Get) pathway. We present the 2A crystal structure of Get4 which participates in early steps of the Get pathway. The structure shows an alpha-solenoid fold with particular deviations from the regular pairwise arrangement of alpha-helices. A conserved hydrophobic groove accommodates the flexible C-terminal region in trans. The structural organization of the Get4 helical hairpin motifs provides a scaffold for protein-protein interactions in the Get pathway.

The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis.,Bozkurt G, Wild K, Amlacher S, Hurt E, Dobberstein B, Sinning I FEBS Lett. 2010 Apr 16;584(8):1509-14. Epub 2010 Mar 3. PMID:20206626<ref>PMID:20206626</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Cbs 144 50]]

[[Category: Bozkurt, G]]

[[Category: Sinning, I]]

[[Category: Wild, K]]

[[Category: Tail-anchored protein biogenesis]]