1qhi

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[[Image:1qhi.gif|left|200px]]
[[Image:1qhi.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1qhi |SIZE=350|CAPTION= <scene name='initialview01'>1qhi</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1qhi", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BPG:9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE'>BPG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1qhi| PDB=1qhi | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qhi OCA], [http://www.ebi.ac.uk/pdbsum/1qhi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qhi RCSB]</span>
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}}
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'''HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE'''
'''HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE'''
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[[Category: Wien, F.]]
[[Category: Wien, F.]]
[[Category: Wright, G.]]
[[Category: Wright, G.]]
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[[Category: alphaherpesvirinae novel inhibitor]]
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[[Category: Alphaherpesvirinae novel inhibitor]]
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[[Category: ds-dna enveloped viruse]]
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[[Category: Ds-dna enveloped viruse]]
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[[Category: herpesviridae]]
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[[Category: Herpesviridae]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: transferase ( phosphotransferase) thymidine kinase]]
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[[Category: Viridae]]
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[[Category: transferase (phosphotransferase) thymidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:16:38 2008''
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[[Category: viridae]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:13:39 2008''
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Revision as of 03:16, 3 May 2008

Image:1qhi.gif

Template:STRUCTURE 1qhi

HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE


Overview

Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.

About this Structure

1QHI is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:9989588 Page seeded by OCA on Sat May 3 06:16:38 2008

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OCA

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