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3p59
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3p59]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P59 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3p59]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P59 FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1793Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p59 OCA], [https://pdbe.org/3p59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p59 RCSB], [https://www.ebi.ac.uk/pdbsum/3p59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p59 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p59 OCA], [https://pdbe.org/3p59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p59 RCSB], [https://www.ebi.ac.uk/pdbsum/3p59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p59 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The three-dimensional structures of noncoding RNA molecules reveal recurring architectural motifs that have been exploited for the design of artificial RNA nanomaterials. Programmed assembly of RNA nanoobjects from autonomously folding tetraloop-receptor complexes as well as junction motifs has been achieved previously through sequence-directed hybridization of complex sets of long oligonucleotides. Due to size and complexity, structural characterization of artificial RNA nanoobjects has been limited to low-resolution microscopy studies. Here we present the design, construction, and crystal structure determination at 2.2 A of the smallest yet square-shaped nanoobject made entirely of double-stranded RNA. The RNA square is comprised of 100 residues and self-assembles from four copies each of two oligonucleotides of 10 and 15 bases length. Despite the high symmetry on the level of secondary structure, the three-dimensional architecture of the square is asymmetric, with all four corners adopting distinct folding patterns. We demonstrate the programmed self-assembly of RNA squares from complex mixtures of corner units and establish a concept to exploit the RNA square as a combinatorial nanoscale platform. | ||
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| - | Self-assembling RNA square.,Dibrov SM, McLean J, Parsons J, Hermann T Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6405-6408. Epub 2011 Apr 4. PMID:21464284<ref>PMID:21464284</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 3p59" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dibrov | + | [[Category: Dibrov S]] |
| - | [[Category: Hermann | + | [[Category: Hermann T]] |
| - | [[Category: McLean | + | [[Category: McLean J]] |
| - | [[Category: Parsons | + | [[Category: Parsons J]] |
| - | + | ||
| - | + | ||
Current revision
First Crystal Structure of a RNA Nanosquare
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