3pd7

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<StructureSection load='3pd7' size='340' side='right'caption='[[3pd7]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
<StructureSection load='3pd7' size='340' side='right'caption='[[3pd7]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l3e 3l3e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PD7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pd7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l3e 3l3e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PD7 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TOPBP1, KIAA0259 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.26&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd7 OCA], [https://pdbe.org/3pd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pd7 RCSB], [https://www.ebi.ac.uk/pdbsum/3pd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pd7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pd7 OCA], [https://pdbe.org/3pd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pd7 RCSB], [https://www.ebi.ac.uk/pdbsum/3pd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pd7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
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[https://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cui, G]]
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[[Category: Cui G]]
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[[Category: Lee, J]]
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[[Category: Lee J]]
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[[Category: Mer, G]]
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[[Category: Mer G]]
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[[Category: Thompson, J R]]
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[[Category: Thompson JR]]
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[[Category: Xu, C]]
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[[Category: Xu C]]
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[[Category: Brct domain]]
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[[Category: Cell cycle]]
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[[Category: Dna repair]]
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Current revision

Crystal Structure of the Sixth BRCT Domain of Human TopBP1

PDB ID 3pd7

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