3ps1

<table><tr><td colspan='2'>[[3ps1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoki Ecoki]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PS1 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UKW:4-ETHYNYL-N-[(1S,2R)-2-HYDROXY-1-(OXOCARBAMOYL)PROPYL]BENZAMIDE'>UKW</scene>, <scene name='pdbligand=ZH2:4-[4-(4-AMINOPHENYL)BUTA-1,3-DIYN-1-YL]-N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]BENZAMIDE'>ZH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECOK1_0097, ENVA, lpxC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714962 ECOKI])</td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/D5CV28_ECOKI D5CV28_ECOKI]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).[HAMAP-Rule:MF_00388][SAAS:SAAS004463_004_013136]

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== Publication Abstract from PubMed ==

Compounds inhibiting LpxC in the lipid A biosynthetic pathway are promising leads for novel antibiotics against multidrug-resistant Gram-negative pathogens. We report the syntheses and structural and biochemical characterizations of LpxC inhibitors based on a diphenyl-diacetylene (1,4-diphenyl-1,3-butadiyne) threonyl-hydroxamate scaffold. These studies provide a molecular interpretation for the differential antibiotic activities of compounds with a substituted distal phenyl ring as well as the absolute stereochemical requirement at the C2, but not C3, position of the threonyl group.

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.,Liang X, Lee CJ, Chen X, Chung HS, Zeng D, Raetz CR, Li Y, Zhou P, Toone EJ Bioorg Med Chem. 2011 Jan 15;19(2):852-60. Epub 2010 Dec 9. PMID:21194954<ref>PMID:21194954</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3ps1" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Ecoki]]

[[Category: Lee, C J]]

[[Category: Zhou, P]]

[[Category: Lpc-011]]