1qhv
From Proteopedia
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'''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD''' | '''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD''' | ||
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[[Category: Louis, N.]] | [[Category: Louis, N.]] | ||
[[Category: Raaij, M J.Van.]] | [[Category: Raaij, M J.Van.]] | ||
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| - | [[Category: | + | [[Category: Receptor binding]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:17:32 2008'' | |
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Revision as of 03:17, 3 May 2008
HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD
Overview
Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.
About this Structure
1QHV is a Single protein structure of sequence from Human adenovirus 2. Full crystallographic information is available from OCA.
Reference
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:10502512 Page seeded by OCA on Sat May 3 06:17:32 2008
