3qs3

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<StructureSection load='3qs3' size='340' side='right'caption='[[3qs3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3qs3' size='340' side='right'caption='[[3qs3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qs3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QS3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qs3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_CFT073 Escherichia coli CFT073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QS3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qs2|3qs2]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">matB, ecpD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs3 OCA], [https://pdbe.org/3qs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qs3 RCSB], [https://www.ebi.ac.uk/pdbsum/3qs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qs3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs3 OCA], [https://pdbe.org/3qs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qs3 RCSB], [https://www.ebi.ac.uk/pdbsum/3qs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qs3 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/ECPD_ECOL6 ECPD_ECOL6] Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity).[https://www.uniprot.org/uniprot/ECPA_ECOL6 ECPA_ECOL6] Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria.<ref>PMID:22355107</ref>
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Bacteria have evolved a variety of mechanisms for developing community-based biofilms. These bacterial aggregates are of clinical importance, as they are a major source of recurrent disease. Bacterial surface fibers (pili) permit adherence to biotic and abiotic substrates, often in a highly specific manner. The Escherichia coli common pilus (ECP) represents a remarkable family of extracellular fibers that are associated with both disease-causing and commensal strains. ECP plays a dual role in early-stage biofilm development and host cell recognition. Despite being the most common fimbrial structure, relatively little is known regarding its biogenesis, architecture, and function. Here we report atomic-resolution insight into the biogenesis and architecture of ECP. We also derive a structural model for entwined ECP fibers that not only illuminates interbacteria communication during biofilm formation but also provides a useful foundation for the design of novel nanofibers.
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Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus.,Garnett JA, Martinez-Santos VI, Saldana Z, Pape T, Hawthorne W, Chan J, Simpson PJ, Cota E, Puente JL, Giron JA, Matthews S Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3950-5. Epub 2012 Feb 21. PMID:22355107<ref>PMID:22355107</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qs3" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli CFT073]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Garnett, J A]]
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[[Category: Garnett JA]]
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[[Category: Matthews, S J]]
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[[Category: Matthews SJ]]
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[[Category: Adhesion]]
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[[Category: Biofilm]]
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[[Category: Cell adhesion]]
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[[Category: Chimera protein]]
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[[Category: Extracellular membrane]]
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[[Category: Fusion protein]]
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[[Category: Ig-like fold]]
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[[Category: Immunoglobulin-like fold]]
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[[Category: Intermolecular and hydrophobic abiotic surface binding]]
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[[Category: Major pilin domain involved in biofilm]]
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[[Category: Pilin]]
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Current revision

Crystal structure of the biofilm forming subunit of the E. coli common pilus: donor strand complemented (DSC) EcpA

PDB ID 3qs3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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