1qi7

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[[Image:1qi7.gif|left|200px]]
[[Image:1qi7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1qi7 |SIZE=350|CAPTION= <scene name='initialview01'>1qi7</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1qi7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1qi7| PDB=1qi7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qi7 OCA], [http://www.ebi.ac.uk/pdbsum/1qi7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qi7 RCSB]</span>
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}}
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'''THE CRYSTAL STRUCTURE AT 2.0 A OF SAPORIN SO6, A RIBOSOME INACTIVATING PROTEIN FROM SAPONARIA OFFICINALIS'''
'''THE CRYSTAL STRUCTURE AT 2.0 A OF SAPORIN SO6, A RIBOSOME INACTIVATING PROTEIN FROM SAPONARIA OFFICINALIS'''
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[[Category: Saponaria officinalis]]
[[Category: Saponaria officinalis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: rRNA N-glycosylase]]
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[[Category: RRNA N-glycosylase]]
[[Category: Federici, L.]]
[[Category: Federici, L.]]
[[Category: Ippoliti, R.]]
[[Category: Ippoliti, R.]]
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[[Category: Savino, C.]]
[[Category: Savino, C.]]
[[Category: Tsernoglou, D.]]
[[Category: Tsernoglou, D.]]
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[[Category: n-glycosidase]]
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[[Category: N-glycosidase]]
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[[Category: ribosome inactivating protein]]
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[[Category: Ribosome inactivating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:18:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:13:57 2008''
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Revision as of 03:18, 3 May 2008

Image:1qi7.gif

Template:STRUCTURE 1qi7

THE CRYSTAL STRUCTURE AT 2.0 A OF SAPORIN SO6, A RIBOSOME INACTIVATING PROTEIN FROM SAPONARIA OFFICINALIS


Overview

The 2.0 A resolution crystal structure of the ribosome inactivating protein saporin (isoform 6) from seeds of Saponaria officinalis is presented. The fold typical of other plant toxins is conserved, despite some differences in the loop regions. The loop between strands beta7 and beta8 in the C-terminal region which spans over the active site cleft appears shorter in saporin, suggesting an easier access to the substrate. Furthermore we investigated the molecular interaction between saporin and the yeast ribosome by differential chemical modifications. A contact surface inside the C-terminal region of saporin has been identified. Structural comparison between saporin and other ribosome inactivating proteins reveals that this region is conserved and represents a peculiar motif involved in ribosome recognition.

About this Structure

1QI7 is a Single protein structure of sequence from Saponaria officinalis. Full crystallographic information is available from OCA.

Reference

The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome., Savino C, Federici L, Ippoliti R, Lendaro E, Tsernoglou D, FEBS Lett. 2000 Mar 31;470(3):239-43. PMID:10745075 Page seeded by OCA on Sat May 3 06:18:12 2008

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