3odv

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<StructureSection load='3odv' size='340' side='right'caption='[[3odv]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
<StructureSection load='3odv' size='340' side='right'caption='[[3odv]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3odv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3odv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_mauritanicus_mauritanicus Androctonus mauritanicus mauritanicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odv OCA], [https://pdbe.org/3odv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odv RCSB], [https://www.ebi.ac.uk/pdbsum/3odv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odv OCA], [https://pdbe.org/3odv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odv RCSB], [https://www.ebi.ac.uk/pdbsum/3odv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA]] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
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[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of d- and l-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1[combining macron] that diffracted to atomic-resolution (0.95 A), enabling the X-ray structure of kaliotoxin to be determined by direct methods.
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Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.,Pentelute BL, Mandal K, Gates ZP, Sawaya MR, Yeates TO, Kent SB Chem Commun (Camb). 2010 Sep 28. PMID:20877851<ref>PMID:20877851</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3odv" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Androctonus mauritanicus mauritanicus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gates, Z P]]
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[[Category: Gates ZP]]
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[[Category: Kent, S B.H]]
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[[Category: Kent SBH]]
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[[Category: Mandal, K]]
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[[Category: Mandal K]]
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[[Category: Pentelute, B L]]
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[[Category: Pentelute BL]]
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[[Category: Sawaya, M R]]
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[[Category: Sawaya MR]]
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[[Category: Yeates, T O]]
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[[Category: Yeates TO]]
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[[Category: Chemical synthesis]]
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[[Category: Direct method]]
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[[Category: Racemic protein]]
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[[Category: Toxin]]
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Revision as of 11:16, 21 February 2024

X-ray structure of kaliotoxin by racemic protein crystallography

PDB ID 3odv

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