5r4w

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==XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13501a==
==XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13501a==
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<StructureSection load='5r4w' size='340' side='right'caption='[[5r4w]]' scene=''>
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<StructureSection load='5r4w' size='340' side='right'caption='[[5r4w]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5R4W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5r4w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5R4W FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5r4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4w OCA], [http://pdbe.org/5r4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5r4w RCSB], [http://www.ebi.ac.uk/pdbsum/5r4w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4w ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RWP:methyl+4-[(trifluoroacetyl)amino]benzoate'>RWP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5r4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4w OCA], [https://pdbe.org/5r4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5r4w RCSB], [https://www.ebi.ac.uk/pdbsum/5r4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4w ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
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==See Also==
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*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aimon A]]
[[Category: Aimon A]]

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XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13501a

PDB ID 5r4w

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