5r4x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:35, 21 February 2024) (edit) (undo)
 
Line 1: Line 1:
==XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13413a==
==XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13413a==
-
<StructureSection load='5r4x' size='340' side='right'caption='[[5r4x]]' scene=''>
+
<StructureSection load='5r4x' size='340' side='right'caption='[[5r4x]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5R4X FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5r4x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5R4X FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5r4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4x OCA], [http://pdbe.org/5r4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5r4x RCSB], [http://www.ebi.ac.uk/pdbsum/5r4x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4x ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K3D:4-acetyl-N-ethylpiperazine-1-carboxamide'>K3D</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5r4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4x OCA], [https://pdbe.org/5r4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5r4x RCSB], [https://www.ebi.ac.uk/pdbsum/5r4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4x ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
 +
 +
==See Also==
 +
*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]]
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aimon A]]
[[Category: Aimon A]]

Current revision

XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13413a

PDB ID 5r4x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5r4x"
Personal tools