8ckk

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'''Unreleased structure'''
 
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The entry 8ckk is ON HOLD until Paper Publication
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==Semaphorin-5A TSR 3-4 domains in complex with nitrate==
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<StructureSection load='8ckk' size='340' side='right'caption='[[8ckk]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ckk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CKK FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ckk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ckk OCA], [https://pdbe.org/8ckk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ckk RCSB], [https://www.ebi.ac.uk/pdbsum/8ckk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ckk ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SEM5A_HUMAN SEM5A_HUMAN] Monosomy 5p.
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== Function ==
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[https://www.uniprot.org/uniprot/SEM5A_HUMAN SEM5A_HUMAN] Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.<ref>PMID:15218527</ref> <ref>PMID:19850054</ref> <ref>PMID:20696765</ref> <ref>PMID:21706053</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Duman R]]
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[[Category: El Omari K]]
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[[Category: Harlos K]]
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[[Category: Jones EY]]
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[[Category: Nagy GN]]
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[[Category: Wagner A]]

Revision as of 09:34, 1 March 2024

Semaphorin-5A TSR 3-4 domains in complex with nitrate

PDB ID 8ckk

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OCA

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