8ckm

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'''Unreleased structure'''
 
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The entry 8ckm is ON HOLD until Paper Publication
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==Semaphorin-5A TSR 3-4 domains==
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<StructureSection load='8ckm' size='340' side='right'caption='[[8ckm]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ckm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CKM FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ckm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ckm OCA], [https://pdbe.org/8ckm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ckm RCSB], [https://www.ebi.ac.uk/pdbsum/8ckm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ckm ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SEM5A_HUMAN SEM5A_HUMAN] Monosomy 5p.
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== Function ==
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[https://www.uniprot.org/uniprot/SEM5A_HUMAN SEM5A_HUMAN] Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.<ref>PMID:15218527</ref> <ref>PMID:19850054</ref> <ref>PMID:20696765</ref> <ref>PMID:21706053</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Duman R]]
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[[Category: El Omari K]]
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[[Category: Harlos K]]
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[[Category: Jones EY]]
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[[Category: Nagy GN]]
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[[Category: Wagner A]]

Revision as of 09:34, 1 March 2024

Semaphorin-5A TSR 3-4 domains

PDB ID 8ckm

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