This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8gag
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cannabinoid receptor 1-Gi complex with novel ligand== | |
| - | + | <StructureSection load='8gag' size='340' side='right'caption='[[8gag]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8gag]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GAG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YVF:methyl+(2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate'>YVF</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gag OCA], [https://pdbe.org/8gag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gag RCSB], [https://www.ebi.ac.uk/pdbsum/8gag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gag ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Basbaum | + | == Function == |
| - | [[Category: Iliopoulos-Tsoutsouvas | + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: O | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Basbaum AI]] | ||
| + | [[Category: Braz JM]] | ||
| + | [[Category: Iliopoulos-Tsoutsouvas C]] | ||
| + | [[Category: Krishna Kumar K]] | ||
| + | [[Category: Makriyannis M]] | ||
| + | [[Category: O'Brien ES]] | ||
| + | [[Category: Shoichet BK]] | ||
| + | [[Category: Tummino TA]] | ||
Current revision
Cannabinoid receptor 1-Gi complex with novel ligand
| |||||||||||
