8ijr

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'''Unreleased structure'''
 
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The entry 8ijr is ON HOLD until 2025-05-28
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==The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine==
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<StructureSection load='8ijr' size='340' side='right'caption='[[8ijr]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ijr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IJR FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=Z0P:(2S)-1-(HEXADECANOYLOXY)-3-HYDROXYPROPAN-2-YL+(11Z)-OCTADEC-11-ENOATE'>Z0P</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ijr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ijr OCA], [https://pdbe.org/8ijr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ijr RCSB], [https://www.ebi.ac.uk/pdbsum/8ijr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ijr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAMD8_HUMAN SAMD8_HUMAN] Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.<ref>PMID:19506037</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cao Y]]
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[[Category: Chen Y]]
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[[Category: Hu K]]
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[[Category: Yao D]]
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[[Category: Zhang Q]]
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[[Category: Zhou L]]

Revision as of 09:37, 1 March 2024

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine

PDB ID 8ijr

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OCA

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