1qkc

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[[Image:1qkc.jpg|left|200px]]
[[Image:1qkc.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1qkc |SIZE=350|CAPTION= <scene name='initialview01'>1qkc</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1qkc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ALB:DELTA-2-ALBOMYCIN+A1'>ALB</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=FTT:3-HYDROXY-TETRADECANOIC+ACID'>FTT</scene>, <scene name='pdbligand=GCN:3-DEOXY-D-GLUCOSAMINE'>GCN</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=GMH:L-GLYCERO-D-MANNO-HEPTOPYRANOSE'>GMH</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PA1:PAROMOMYCIN+(RING+1)'>PA1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= FHUA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1qkc| PDB=1qkc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkc OCA], [http://www.ebi.ac.uk/pdbsum/1qkc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qkc RCSB]</span>
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}}
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'''ESCHERICHIA COLI FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) IN COMPLEX DELTA TWO-ALBOMYCIN'''
'''ESCHERICHIA COLI FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) IN COMPLEX DELTA TWO-ALBOMYCIN'''
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[[Category: Fiedler, H P.]]
[[Category: Fiedler, H P.]]
[[Category: Welte, W.]]
[[Category: Welte, W.]]
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[[Category: active transporter]]
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[[Category: Active transporter]]
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[[Category: albomycin]]
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[[Category: Albomycin]]
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[[Category: antibiotic]]
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[[Category: Antibiotic]]
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[[Category: ferrichrome]]
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[[Category: Ferrichrome]]
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[[Category: integral outer membrane protein]]
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[[Category: Integral outer membrane protein]]
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[[Category: iron transport protein]]
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[[Category: Iron transport protein]]
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[[Category: siderophore receptor]]
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[[Category: Siderophore receptor]]
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[[Category: tonb-dependent receptor]]
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[[Category: Tonb-dependent receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:22:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:14:55 2008''
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Revision as of 03:22, 3 May 2008

Image:1qkc.jpg

Template:STRUCTURE 1qkc

ESCHERICHIA COLI FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) IN COMPLEX DELTA TWO-ALBOMYCIN


Overview

One alternative method for drug delivery involves the use of siderophore-antibiotic conjugates. These compounds represent a specific means by which potent antimicrobial agents, covalently linked to iron-chelating siderophores, can be actively transported across the outer membrane of gram-negative bacteria. These "Trojan Horse" antibiotics may prove useful as an efficient means to combat multi-drug-resistant bacterial infections. Here we present the crystallographic structures of the natural siderophore-antibiotic conjugate albomycin and the siderophore phenylferricrocin, in complex with the active outer membrane transporter FhuA from Escherichia coli. To our knowledge, this represents the first structure of an antibiotic bound to its cognate transporter. Albomycins are broad-host range antibiotics that consist of a hydroxamate-type iron-chelating siderophore, and an antibiotically active, thioribosyl pyrimidine moiety. As observed with other hydroxamate-type siderophores, the three-dimensional structure of albomycin reveals an identical coordination geometry surrounding the ferric iron atom. Unexpectedly, this antibiotic assumes two conformational isomers in the binding site of FhuA, an extended and a compact form. The structural information derived from this study provides novel insights into the diverse array of antibiotic moieties that can be linked to the distal portion of iron-chelating siderophores and offers a structural platform for the rational design of hydroxamate-type siderophore-antibiotic conjugates.

About this Structure

1QKC is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the antibiotic albomycin in complex with the outer membrane transporter FhuA., Ferguson AD, Braun V, Fiedler HP, Coulton JW, Diederichs K, Welte W, Protein Sci. 2000 May;9(5):956-63. PMID:10850805 Page seeded by OCA on Sat May 3 06:22:34 2008

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