1qkl

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[[Image:1qkl.jpg|left|200px]]
[[Image:1qkl.jpg|left|200px]]
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{{Structure
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|PDB= 1qkl |SIZE=350|CAPTION= <scene name='initialview01'>1qkl</scene>
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The line below this paragraph, containing "STRUCTURE_1qkl", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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{{STRUCTURE_1qkl| PDB=1qkl | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkl OCA], [http://www.ebi.ac.uk/pdbsum/1qkl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qkl RCSB]</span>
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'''HRPABC14.4, ESSENTIAL SUBUNIT OF HUMAN RNA POLYMERASES I, II AND III'''
'''HRPABC14.4, ESSENTIAL SUBUNIT OF HUMAN RNA POLYMERASES I, II AND III'''
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[[Category: Ladias, J A.A.]]
[[Category: Ladias, J A.A.]]
[[Category: Wagner, G.]]
[[Category: Wagner, G.]]
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[[Category: rna polymerase]]
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[[Category: Rna polymerase]]
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[[Category: transcription]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:23:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:15:02 2008''
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Revision as of 03:23, 3 May 2008

Image:1qkl.jpg

Template:STRUCTURE 1qkl

HRPABC14.4, ESSENTIAL SUBUNIT OF HUMAN RNA POLYMERASES I, II AND III


Overview

The protein hRPABC14.4 is an essential subunit of human RNA polymerases I, II, and III and is required for the transcription of all human nuclear genes. The structure of hRPABC14.4 was determined by nuclear magnetic resonance spectroscopy. The protein fold comprises a highly conserved central domain forming two antiparallel alpha-helices flanked by the less conserved N- and C-terminal regions forming a five-stranded beta-sandwich. Amino acids from the two helices participate in the generation of a hydrophobic surface area which is conserved in all eukaryotic and archaeal homologous subunits, and likely constitutes a critical macromolecular interaction interface. The hRPABC14.4 structure accounts for mutagenesis results in Saccharomyces cerevisiae and provides a structural working model for elucidating the role of this subunit in the molecular architecture and function of the human nuclear RNA polymerases.

About this Structure

1QKL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the hRPABC14.4 subunit of human RNA polymerases., del Rio-Portilla F, Gaskell A, Gilbert D, Ladias JA, Wagner G, Nat Struct Biol. 1999 Nov;6(11):1039-42. PMID:10542096 Page seeded by OCA on Sat May 3 06:23:09 2008

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