3rw7

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Current revision (09:45, 1 March 2024) (edit) (undo)
 
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<StructureSection load='3rw7' size='340' side='right'caption='[[3rw7]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3rw7' size='340' side='right'caption='[[3rw7]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rw7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RW7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rw7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RW7 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rw6|3rw6]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NXF1, TAP, TAP (NXF1) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rw7 OCA], [https://pdbe.org/3rw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rw7 RCSB], [https://www.ebi.ac.uk/pdbsum/3rw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rw7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rw7 OCA], [https://pdbe.org/3rw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rw7 RCSB], [https://www.ebi.ac.uk/pdbsum/3rw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rw7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NXF1_HUMAN NXF1_HUMAN]] Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.<ref>PMID:9660949</ref> <ref>PMID:19165146</ref>
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[https://www.uniprot.org/uniprot/NXF1_HUMAN NXF1_HUMAN] Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.<ref>PMID:9660949</ref> <ref>PMID:19165146</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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mRNA export is mediated by the TAP-p15 heterodimer, which belongs to the family of NTF2-like export receptors. TAP-p15 heterodimers also bind to the constitutive transport element (CTE) present in simian type D retroviral RNAs, and they mediate the export of viral unspliced RNAs to the host cytoplasm. We have solved the crystal structure of the RNA recognition and leucine-rich repeat motifs of TAP bound to one symmetrical half of the CTE RNA. L-shaped conformations of protein and RNA are involved in a mutual molecular embrace on complex formation. We have monitored the impact of structure-guided mutations on binding affinities in vitro and transport assays in vivo. Our studies define the principles by which CTE RNA subverts the mRNA export receptor TAP, thereby facilitating the nuclear export of viral genomic RNAs, and, more generally, provide insights on cargo RNA recognition by mRNA export receptors.
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Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP.,Teplova M, Wohlbold L, Khin NW, Izaurralde E, Patel DJ Nat Struct Mol Biol. 2011 Aug 7;18(9):990-8. doi: 10.1038/nsmb.2094. PMID:21822283<ref>PMID:21822283</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rw7" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Izaurralde, E]]
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[[Category: Izaurralde E]]
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[[Category: Khin, N W]]
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[[Category: Khin NW]]
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[[Category: Patel, D J]]
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[[Category: Patel DJ]]
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[[Category: Teplova, M]]
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[[Category: Teplova M]]
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[[Category: Wohlbold, L]]
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[[Category: Wohlbold L]]
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[[Category: Rna binding protein]]
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[[Category: Transport protein]]
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Current revision

Structure of N-terminal domain of nuclear RNA export factor TAP

PDB ID 3rw7

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