3rzf

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Current revision (09:46, 1 March 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3rzf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qad 3qad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZF FirstGlance]. <br>
<table><tr><td colspan='2'>[[3rzf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qad 3qad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XNM:(4-{[4-(4-CHLOROPHENYL)PYRIMIDIN-2-YL]AMINO}PHENYL)[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE'>XNM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qa8|3qa8]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XNM:(4-{[4-(4-CHLOROPHENYL)PYRIMIDIN-2-YL]AMINO}PHENYL)[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE'>XNM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzf OCA], [https://pdbe.org/3rzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzf RCSB], [https://www.ebi.ac.uk/pdbsum/3rzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzf OCA], [https://pdbe.org/3rzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzf RCSB], [https://www.ebi.ac.uk/pdbsum/3rzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzf ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6INT1_XENLA Q6INT1_XENLA]
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Inhibitor of kappaB (IkappaB) kinase (IKK) phosphorylates IkappaB proteins, leading to their degradation and the liberation of nuclear factor kappaB for gene transcription. Here we report the crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A. The structure reveals a trimodular architecture comprising the kinase domain, a ubiquitin-like domain (ULD) and an elongated, alpha-helical scaffold/dimerization domain (SDD). Unexpectedly, the predicted leucine zipper and helix-loop-helix motifs do not form these structures but are part of the SDD. The ULD and SDD mediate a critical interaction with IkappaBalpha that restricts substrate specificity, and the ULD is also required for catalytic activity. The SDD mediates IKKbeta dimerization, but dimerization per se is not important for maintaining IKKbeta activity and instead is required for IKKbeta activation. Other IKK family members, IKKalpha, TBK1 and IKK-i, may have a similar trimodular architecture and function.
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Crystal structure of inhibitor of kappaB kinase beta,Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H Nature. 2011 Mar 20. PMID:21423167<ref>PMID:21423167</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rzf" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Dreano, M]]
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[[Category: Dreano M]]
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[[Category: Jiang, X]]
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[[Category: Jiang X]]
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[[Category: Karin, M]]
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[[Category: Karin M]]
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[[Category: Li, Q]]
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[[Category: Li Q]]
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[[Category: Lo, Y C]]
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[[Category: Lo YC]]
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[[Category: Napolitano, G]]
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[[Category: Napolitano G]]
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[[Category: Wu, H]]
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[[Category: Wu H]]
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[[Category: Wu, X]]
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[[Category: Wu X]]
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[[Category: Xu, G]]
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[[Category: Xu G]]
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[[Category: I kappa b alpha]]
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[[Category: Immune system]]
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[[Category: Kinase]]
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[[Category: Kinase ubiquitin-like domain scaffold helix]]
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[[Category: Kinase uld]]
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[[Category: Phosphorylation]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of Inhibitor of kappaB kinase beta (I4122)

PDB ID 3rzf

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