3seo

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Current revision (09:49, 1 March 2024) (edit) (undo)
 
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<StructureSection load='3seo' size='340' side='right'caption='[[3seo]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
<StructureSection load='3seo' size='340' side='right'caption='[[3seo]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3seo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"oceanomonas_parahaemolytica"_(fujino_et_al._1951)_miyamoto_et_al._1961 "oceanomonas parahaemolytica" (fujino et al. 1951) miyamoto et al. 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SEO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3seo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus Vibrio parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SEO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.305&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VopL, VPA1370 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=670 "Oceanomonas parahaemolytica" (Fujino et al. 1951) Miyamoto et al. 1961])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3seo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seo OCA], [https://pdbe.org/3seo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3seo RCSB], [https://www.ebi.ac.uk/pdbsum/3seo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3seo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3seo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seo OCA], [https://pdbe.org/3seo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3seo RCSB], [https://www.ebi.ac.uk/pdbsum/3seo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3seo ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q87GE5_VIBPA Q87GE5_VIBPA]
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Vibrio parahaemolyticus protein L (VopL) is an actin nucleation factor that induces stress fibers when injected into eukaryotic host cells. VopL contains three N-terminal Wiskott-Aldrich homology 2 (WH2) motifs and a unique VopL C-terminal domain (VCD). We describe crystallographic and biochemical analyses of filament nucleation by VopL. The WH2 element of VopL does not nucleate on its own and requires the VCD for activity. The VCD forms a U-shaped dimer in the crystal, stabilized by a terminal coiled coil. Dimerization of the WH2 motifs contributes strongly to nucleation activity, as do contacts of the VCD to actin. Our data lead to a model in which VopL stabilizes primarily lateral (short-pitch) contacts between actin monomers to create the base of a two-stranded filament. Stabilization of lateral contacts may be a common feature of actin filament nucleation by WH2-based factors.
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Mechanism of actin filament nucleation by the bacterial effector VopL.,Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK Nat Struct Mol Biol. 2011 Aug 28;18(9):1068-74. doi: 10.1038/nsmb.2110. PMID:21873984<ref>PMID:21873984</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3seo" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Rosen, M K]]
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[[Category: Vibrio parahaemolyticus]]
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[[Category: Tomchick, D R]]
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[[Category: Rosen MK]]
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[[Category: Yu, B]]
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[[Category: Tomchick DR]]
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[[Category: Alpha helix]]
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[[Category: Yu B]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of VopL C terminal domain

PDB ID 3seo

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