3tij

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Current revision (10:09, 1 March 2024) (edit) (undo)
 
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<StructureSection load='3tij' size='340' side='right'caption='[[3tij]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
<StructureSection load='3tij' size='340' side='right'caption='[[3tij]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TIJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TIJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.436&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VC_2352 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tij OCA], [https://pdbe.org/3tij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tij RCSB], [https://www.ebi.ac.uk/pdbsum/3tij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tij ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tij OCA], [https://pdbe.org/3tij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tij RCSB], [https://www.ebi.ac.uk/pdbsum/3tij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tij ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9KPL5_VIBCH Q9KPL5_VIBCH]
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Nucleosides are required for DNA and RNA synthesis, and the nucleoside adenosine has a function in a variety of signalling processes. Transport of nucleosides across cell membranes provides the major source of nucleosides in many cell types and is also responsible for the termination of adenosine signalling. As a result of their hydrophilic nature, nucleosides require a specialized class of integral membrane proteins, known as nucleoside transporters (NTs), for specific transport across cell membranes. In addition to nucleosides, NTs are important determinants for the transport of nucleoside-derived drugs across cell membranes. A wide range of nucleoside-derived drugs, including anticancer drugs (such as Ara-C and gemcitabine) and antiviral drugs (such as zidovudine and ribavirin), have been shown to depend, at least in part, on NTs for transport across cell membranes. Concentrative nucleoside transporters, members of the solute carrier transporter superfamily SLC28, use an ion gradient in the active transport of both nucleosides and nucleoside-derived drugs against their chemical gradients. The structural basis for selective ion-coupled nucleoside transport by concentrative nucleoside transporters is unknown. Here we present the crystal structure of a concentrative nucleoside transporter from Vibrio cholerae in complex with uridine at 2.4 A. Our functional data show that, like its human orthologues, the transporter uses a sodium-ion gradient for nucleoside transport. The structure reveals the overall architecture of this class of transporter, unravels the molecular determinants for nucleoside and sodium binding, and provides a framework for understanding the mechanism of nucleoside and nucleoside drug transport across cell membranes.
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Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 A.,Johnson ZL, Cheong CG, Lee SY Nature. 2012 Mar 11;483(7390):489-93. doi: 10.1038/nature10882. PMID:22407322<ref>PMID:22407322</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3tij" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillo virgola del koch trevisan 1884]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cheong, C G]]
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[[Category: Vibrio cholerae]]
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[[Category: Johnson, Z L]]
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[[Category: Cheong C-G]]
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[[Category: Lee, S Y]]
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[[Category: Johnson ZL]]
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[[Category: Drug transporter]]
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[[Category: Lee S-Y]]
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[[Category: Membrane protein]]
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[[Category: Membrane transporter]]
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[[Category: Nucleoside]]
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[[Category: Nucleoside transporter]]
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[[Category: Uridine]]
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Current revision

Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae

PDB ID 3tij

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