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1ql5

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[[Image:1ql5.gif|left|200px]]
[[Image:1ql5.gif|left|200px]]
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{{Structure
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|PDB= 1ql5 |SIZE=350|CAPTION= <scene name='initialview01'>1ql5</scene>
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The line below this paragraph, containing "STRUCTURE_1ql5", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=PBT:[3-HYDROXY-5-(5-METHYL-2,4-DIOXOTETRAHYDRO-1(2H)-PYRIMIDINYL)TETRAHYDRO-2-FURANYL]METHYL+DIHYDROGEN+PHOSPHATE'>PBT</scene>
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{{STRUCTURE_1ql5| PDB=1ql5 | SCENE= }}
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|RELATEDENTRY=[[1cfl|1CFL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ql5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ql5 OCA], [http://www.ebi.ac.uk/pdbsum/1ql5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ql5 RCSB]</span>
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'''DNA DECAMER DUPLEX CONTAINING T5-T6 PHOTOADDUCT'''
'''DNA DECAMER DUPLEX CONTAINING T5-T6 PHOTOADDUCT'''
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==About this Structure==
==About this Structure==
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1QL5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QL5 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QL5 OCA].
==Reference==
==Reference==
Solution structure of the DNA decamer duplex containing a 3'-T x T basepair of the cis-syn cyclobutane pyrimidine dimer: implication for the mutagenic property of the cis-syn dimer., Lee JH, Choi YJ, Choi BS, Nucleic Acids Res. 2000 Apr 15;28(8):1794-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10734199 10734199]
Solution structure of the DNA decamer duplex containing a 3'-T x T basepair of the cis-syn cyclobutane pyrimidine dimer: implication for the mutagenic property of the cis-syn dimer., Lee JH, Choi YJ, Choi BS, Nucleic Acids Res. 2000 Apr 15;28(8):1794-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10734199 10734199]
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[[Category: Protein complex]]
 
[[Category: Choi, B S.]]
[[Category: Choi, B S.]]
[[Category: Hwang, G S.]]
[[Category: Hwang, G S.]]
[[Category: Lee, J H.]]
[[Category: Lee, J H.]]
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[[Category: (6-4) adduct]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: deoxyribonucleic acid]]
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[[Category: Dna photoproduct]]
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[[Category: dna photoproduct]]
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[[Category: Mutagenesis]]
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[[Category: mutagenesis]]
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[[Category: Nmr]]
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[[Category: nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:24:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:15:16 2008''
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Revision as of 03:24, 3 May 2008

Image:1ql5.gif

Template:STRUCTURE 1ql5

DNA DECAMER DUPLEX CONTAINING T5-T6 PHOTOADDUCT


Overview

The cis - syn dimer is the major DNA photoproduct produced by UV irradiation. In order to determine the origin of the mutagenic property of the cis - syn dimer, we used NMR restraints and molecular dynamics to determine the solution structure of a DNA decamer duplex containing a wobble pair between the 3'-T of the cis - syn dimer and the opposite T residue (CS/TA duplex). The solution structure of the CS/TA duplex revealed that the 3'-T x T base pair of the cis - syn dimer had base pair geometry that was significantly different from the canonical Watson-Crick base pair and caused destabilization and conformational distortion of its 3'-region. However, a 3'-T x A base pair at the cis - syn dimer within this related DNA decamer maintains the normal Watson-Crick base pair geometry and causes little distortion in the conformation of its 3'-side. Our results show that in spite of its stable hydrogen bonding, the insertion of a T residue opposite the 3'-T of the cis - syn dimer is inhibited by structural distortion caused by the 3'-T x T base pair. This may explain why the frequency of the 3'-T-->A transversion, which is the major mutation produced by the cis - syn dimer, is only 4%.

About this Structure

Full crystallographic information is available from OCA.

Reference

Solution structure of the DNA decamer duplex containing a 3'-T x T basepair of the cis-syn cyclobutane pyrimidine dimer: implication for the mutagenic property of the cis-syn dimer., Lee JH, Choi YJ, Choi BS, Nucleic Acids Res. 2000 Apr 15;28(8):1794-801. PMID:10734199 Page seeded by OCA on Sat May 3 06:24:20 2008

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