1qlf
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1qlf.jpg|left|200px]] | [[Image:1qlf.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1qlf", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1qlf| PDB=1qlf | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G''' | '''MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G''' | ||
| Line 29: | Line 26: | ||
[[Category: Jones, E Y.]] | [[Category: Jones, E Y.]] | ||
[[Category: Tormo, J.]] | [[Category: Tormo, J.]] | ||
| - | [[Category: | + | [[Category: Antigen]] |
| - | [[Category: | + | [[Category: Glycopeptide]] |
| - | [[Category: | + | [[Category: Histocompatibility]] |
| - | [[Category: | + | [[Category: Immunology]] |
| - | [[Category: | + | [[Category: Mhc]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:24:47 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:24, 3 May 2008
MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G
Overview
Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.
About this Structure
1QLF is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Sendai virus. Full crystallographic information is available from OCA.
Reference
Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity., Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend A, Pao YL, Wormald M, Dwek RA, Jones EY, Elliott T, Immunity. 1999 Jan;10(1):63-74. PMID:10023771 Page seeded by OCA on Sat May 3 06:24:47 2008
