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3u6n

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Current revision (10:17, 1 March 2024) (edit) (undo)
 
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<StructureSection load='3u6n' size='340' side='right'caption='[[3u6n]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
<StructureSection load='3u6n' size='340' side='right'caption='[[3u6n]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.61&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [https://pdbe.org/3u6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [https://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [https://pdbe.org/3u6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [https://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/B7ZC96_DANRE B7ZC96_DANRE]
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High-conductance voltage- and Ca(2+)-activated K(+) channels function in many physiological processes that link cell membrane voltage and intracellular Ca(2+) concentration, including neuronal electrical activity, skeletal and smooth muscle contraction, and hair cell tuning. Like other voltage-dependent K(+) channels, Ca(2+)-activated K(+) channels open when the cell membrane depolarizes, but in contrast to other voltage-dependent K(+) channels, they also open when intracellular Ca(2+) concentrations rise. Channel opening by Ca(2+) is made possible by a structure called the gating ring, which is located in the cytoplasm. Recent structural studies have defined the Ca(2+)-free, closed, conformation of the gating ring, but the Ca(2+)-bound, open, conformation is not yet known. Here we present the Ca(2+)-bound conformation of the gating ring. This structure shows how one layer of the gating ring, in response to the binding of Ca(2+), opens like the petals of a flower. The degree to which it opens explains how Ca(2+) binding can open the transmembrane pore. These findings present a molecular basis for Ca(2+) activation of K(+) channels and suggest new possibilities for targeting the gating ring to treat conditions such as asthma and hypertension.
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Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.,Yuan P, Leonetti MD, Hsiung Y, MacKinnon R Nature. 2011 Dec 4;481(7379):94-7. doi: 10.1038/nature10670. PMID:22139424<ref>PMID:22139424</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3u6n" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: MacKinnon, R]]
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[[Category: MacKinnon R]]
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[[Category: Yuan, P]]
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[[Category: Yuan P]]
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[[Category: Potassium channel]]
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[[Category: Transport protein]]
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Current revision

Open Structure of the BK channel Gating Ring

PDB ID 3u6n

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