3uel
From Proteopedia
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<StructureSection load='3uel' size='340' side='right'caption='[[3uel]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='3uel' size='340' side='right'caption='[[3uel]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3uel]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3uel]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UEL FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1R:5-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE'>A1R</scene></td></tr> | |
| - | <tr id=' | + | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uel OCA], [https://pdbe.org/3uel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uel RCSB], [https://www.ebi.ac.uk/pdbsum/3uel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uel ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uel OCA], [https://pdbe.org/3uel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uel RCSB], [https://www.ebi.ac.uk/pdbsum/3uel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uel ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PARG_RAT PARG_RAT] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity). | |
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==See Also== | ==See Also== | ||
*[[Poly(ADP-ribose) glycohydrolase 3D structures|Poly(ADP-ribose) glycohydrolase 3D structures]] | *[[Poly(ADP-ribose) glycohydrolase 3D structures|Poly(ADP-ribose) glycohydrolase 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Classen | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Ellenberger | + | [[Category: Classen S]] |
| - | [[Category: Kiefer | + | [[Category: Ellenberger T]] |
| - | [[Category: Kim | + | [[Category: Kiefer JR]] |
| - | [[Category: Stegemann | + | [[Category: Kim IK]] |
| - | [[Category: Tainer | + | [[Category: Stegemann RA]] |
| - | + | [[Category: Tainer JA]] | |
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Current revision
Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase bound to ADP-HPD
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