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1qmc

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[[Image:1qmc.gif|left|200px]]
[[Image:1qmc.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmc OCA], [http://www.ebi.ac.uk/pdbsum/1qmc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qmc RCSB]</span>
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'''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES'''
'''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES'''
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[[Category: Plasterk, R H.A.]]
[[Category: Plasterk, R H.A.]]
[[Category: Sprangers, R.]]
[[Category: Sprangers, R.]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: dna-binding protein]]
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[[Category: Dna-binding protein]]
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[[Category: integrase]]
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[[Category: Integrase]]
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[[Category: polyprotein]]
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[[Category: Polyprotein]]
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[[Category: src homology 3 (sh3)-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:26:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:15:53 2008''
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Revision as of 03:26, 3 May 2008

Image:1qmc.gif

Template:STRUCTURE 1qmc

C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES


Overview

The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus the average of 0.46 A. Correlation of the structure with recent mutagenesis studies suggests two possible models for DNA binding. Proteins 1999;36:556-564.

About this Structure

1QMC is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase., Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R, Proteins. 1999 Sep 1;36(4):556-64. PMID:10450096 Page seeded by OCA on Sat May 3 06:26:51 2008

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