4icb

<table><tr><td colspan='2'>[[4icb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ICB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ICB FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4icb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4icb OCA], [http://pdbe.org/4icb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4icb RCSB], [http://www.ebi.ac.uk/pdbsum/4icb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4icb ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

In a structure of recombinant bovine calbindin D9k, determined crystallographically to 1.6 A resolution, a proline in mixed, approximately equally populated, cis and trans conformation is observed. Isomers of this kind have not been reported in structure determinations of calbindin D9k to 2.3 A resolution or in any other crystallographically determined protein structure. The cis-trans isomerization occurs at the peptide bond between Gly42 and Pro43, which is in agreement with results from two-dimensional 1H nuclear magnetic resonance spectroscopy experiments on solutions of calbindin D9k. Alternative backbone stretches have been modeled and refined by stereochemical restrained least-squares refinement for the segment Lys41 to Pro43. The final R-value was 0.188. The structural perturbations accompanying the cis-trans isomerization are found to be very localized. The largest positional differences are observed at residue Gly42, in which the alternative positions of the oxygen atom are 3.6 A apart.

Proline cis-trans isomers in calbindin D9k observed by X-ray crystallography.,Svensson LA, Thulin E, Forsen S J Mol Biol. 1992 Feb 5;223(3):601-6. PMID:1542107<ref>PMID:1542107</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 4icb" style="background-color:#fffaf0;"></div>

*[[S100 protein|S100 protein]]

[[Category: Bovin]]

[[Category: Svensson, L A]]

[[Category: Calcium-binding protein]]