1qnd
From Proteopedia
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[[Image:1qnd.gif|left|200px]] | [[Image:1qnd.gif|left|200px]] | ||
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'''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES''' | '''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES''' | ||
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[[Category: Szyperski, T.]] | [[Category: Szyperski, T.]] | ||
[[Category: Wuthrich, K.]] | [[Category: Wuthrich, K.]] | ||
| - | [[Category: | + | [[Category: Lipid binding]] |
| - | [[Category: | + | [[Category: Nitroxide spin label]] |
| - | [[Category: | + | [[Category: Protein dynamic]] |
| - | [[Category: | + | [[Category: Protein structure]] |
| - | [[Category: | + | [[Category: Sterol carrier protein 2]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:28:52 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:28, 3 May 2008
STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES
Overview
The determination of the NMR structure of the sterol carrier protein-2 (SCP2), analysis of backbone (15)N spin relaxation parameters and NMR studies of nitroxide spin-labeled substrate binding are presented as a new basis for investigations of the mode of action of SCP2. The SCP2 fold is formed by a five-stranded beta-sheet and four alpha-helices. Fatty acid binding to a hydrophobic surface area formed by amino acid residues of the first and third helices, and the beta-sheet, which are all located in the polypeptide segment 8-102, was identified with the use of the spin-labeled substrate 16-doxylstearic acid. In the free protein, the lipid-binding site is covered by the C-terminal segment 105-123, suggesting that this polypeptide segment, which carries the peroxisomal targeting signal (PTS1), might be involved in the regulation of ligand binding.
About this Structure
1QND is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of the sterol carrier protein-2: implications for the biological role., Garcia FL, Szyperski T, Dyer JH, Choinowski T, Seedorf U, Hauser H, Wuthrich K, J Mol Biol. 2000 Jan 21;295(3):595-603. PMID:10623549 Page seeded by OCA on Sat May 3 06:28:52 2008
