4me3
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4me3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ME3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ME3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4me3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ME3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ME3 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.794Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4me3 OCA], [https://pdbe.org/4me3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4me3 RCSB], [https://www.ebi.ac.uk/pdbsum/4me3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4me3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4me3 OCA], [https://pdbe.org/4me3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4me3 RCSB], [https://www.ebi.ac.uk/pdbsum/4me3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4me3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Q9HK10_THEAC Q9HK10_THEAC] | [https://www.uniprot.org/uniprot/Q9HK10_THEAC Q9HK10_THEAC] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Mini-chromosome maintenance (MCM) proteins are the replicative helicase necessary for DNA replication in both eukarya and archaea. Most of archaea only have one MCM gene. Here, we report a 1.8-A crystal structure of the N-terminal MCM from the archaeon Thermoplasma acidophilum (tapMCM). In the structure, the MCM N-terminus forms a right-handed filament that contains six subunits in each turn, with a diameter of 25A of the central channel opening. The inner surface is highly positively charged, indicating DNA binding. This filament structure with six subunits per turn may also suggests a potential role for an open-ring structure for hexameric MCM and dynamic conformational changes in initiation and elongation stages of DNA replication. | ||
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| - | The 1.8-A Crystal Structure of the N-Terminal Domain of an Archaeal MCM as a Right-Handed Filament.,Fu Y, Slaymaker IM, Wang J, Wang G, Chen XS J Mol Biol. 2013 Dec 27. pii: S0022-2836(13)00812-7. doi:, 10.1016/j.jmb.2013.12.025. PMID:24378617<ref>PMID:24378617</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4me3" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
1.8 Angstrom Crystal Structure of the N-terminal Domain of an Archaeal MCM
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