7t0x

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<StructureSection load='7t0x' size='340' side='right'caption='[[7t0x]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
<StructureSection load='7t0x' size='340' side='right'caption='[[7t0x]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7t0x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7t0x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0X FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0x OCA], [https://pdbe.org/7t0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0x RCSB], [https://www.ebi.ac.uk/pdbsum/7t0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0x ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0x OCA], [https://pdbe.org/7t0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0x RCSB], [https://www.ebi.ac.uk/pdbsum/7t0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0x ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/PSMA3_STAA8 PSMA3_STAA8] Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
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SignificanceThe formation of cross-alpha amyloids has been shown by crystallographic analysis of the highly cytolytic peptide PSMalpha3, a secreted virulence factor associated with the human pathogen Staphylococcus aureus. However, the relationship of the crystallographic cross-alpha structure to self-assembled filaments of PSMalpha3 and its relevance to other phenol-soluble modulin (PSM) peptides remained an open question. We report the cryo-electron microscopy structural analysis of three nanotubes derived from self-assembly of PSMalpha3 and PSMbeta2 peptides in aqueous solution. In each case, the nanotubes are derived from self-association of cross-alpha amyloid protofilaments. The self-assembly behavior of S. aureus PSMalpha3 and PSMbeta2 peptides provides strong evidence for the importance of the cross-alpha fold in self-assembled peptide and protein structures in general and for PSMs in particular.
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Phenol-soluble modulins PSMalpha3 and PSMbeta2 form nanotubes that are cross-alpha amyloids.,Kreutzberger MAB, Wang S, Beltran LC, Tuachi A, Zuo X, Egelman EH, Conticello VP Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2121586119. doi:, 10.1073/pnas.2121586119. Epub 2022 May 9. PMID:35533283<ref>PMID:35533283</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7t0x" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Beltran, L C]]
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[[Category: Staphylococcus aureus]]
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[[Category: Conticello, V P]]
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[[Category: Beltran LC]]
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[[Category: Egelman, E H]]
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[[Category: Conticello VP]]
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[[Category: Kreutzberger, M A]]
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[[Category: Egelman EH]]
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[[Category: Wang, S]]
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[[Category: Kreutzberger MA]]
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[[Category: Amyloid]]
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[[Category: Wang S]]
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[[Category: Cross-alpha]]
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[[Category: Nanotube]]
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[[Category: Protein fibril]]
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Current revision

Structure of the larger diameter PSMalpha3 nanotube

PDB ID 7t0x

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OCA

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