7t26
From Proteopedia
(Difference between revisions)
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==Structure of phage FBB1 anti-CBASS nuclease Acb1 in apo state== | ==Structure of phage FBB1 anti-CBASS nuclease Acb1 in apo state== | ||
| - | <StructureSection load='7t26' size='340' side='right'caption='[[7t26]]' scene=''> | + | <StructureSection load='7t26' size='340' side='right'caption='[[7t26]], [[Resolution|resolution]] 1.14Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T26 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Erwinia_phage_FBB1 Erwinia phage FBB1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T26 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t26 OCA], [https://pdbe.org/7t26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t26 RCSB], [https://www.ebi.ac.uk/pdbsum/7t26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t26 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.14Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t26 OCA], [https://pdbe.org/7t26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t26 RCSB], [https://www.ebi.ac.uk/pdbsum/7t26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t26 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACB1_BPFBB ACB1_BPFBB] Counteracts the host CBASS antiviral defense system. Phosphodiesterase that enables metal-independent hydrolysis of the host cyclic di- and trinucleotide CBASS signals such as 3'3'-cGAMP, 3'3'cUA, and 3'3'3'-cAAA (PubMed:35395152). Does not cleave cGG or cA4 (By similarity). Besides evasion of the CBASS system, might also enable evasion of the type III CRISPR systems that use cA3 signals (By similarity).[UniProtKB:P04533]<ref>PMID:35395152</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Erwinia phage FBB1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hobbs SJ]] | [[Category: Hobbs SJ]] | ||
Current revision
Structure of phage FBB1 anti-CBASS nuclease Acb1 in apo state
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Categories: Erwinia phage FBB1 | Large Structures | Hobbs SJ | Kranzusch PJ | Lu A | Morehouse BR | Schnabel J | Sorek R | Wein T
