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7t6q
From Proteopedia
(Difference between revisions)
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==Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs== | ==Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs== | ||
| - | <StructureSection load='7t6q' size='340' side='right'caption='[[7t6q]]' scene=''> | + | <StructureSection load='7t6q' size='340' side='right'caption='[[7t6q]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T6Q FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t6q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T6Q FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t6q OCA], [https://pdbe.org/7t6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t6q RCSB], [https://www.ebi.ac.uk/pdbsum/7t6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t6q ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t6q OCA], [https://pdbe.org/7t6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t6q RCSB], [https://www.ebi.ac.uk/pdbsum/7t6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t6q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRPV5_RABIT TRPV5_RABIT] Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).[UniProtKB:P69744][UniProtKB:Q9NQA5]<ref>PMID:10085067</ref> <ref>PMID:11035011</ref> <ref>PMID:12574114</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Fluck EC]] | [[Category: Fluck EC]] | ||
[[Category: Moiseenkova-Bell VY]] | [[Category: Moiseenkova-Bell VY]] | ||
[[Category: Rohacs T]] | [[Category: Rohacs T]] | ||
[[Category: Yazici AT]] | [[Category: Yazici AT]] | ||
Current revision
Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs
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