1svc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1svc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1svc, resolution 2.600&Aring;" /> '''NFKB P50 HOMODIMER...)
Next diff →

Revision as of 17:11, 12 November 2007

Image:1svc.gif

1svc, resolution 2.600Å

Drag the structure with the mouse to rotate

NFKB P50 HOMODIMER BOUND TO DNA

Overview

The structure of a large fragment of the p50 subunit of the human, transcription factor NF-kappa B, bound as a homodimer to DNA, reveals that, the Rel-homology region has two beta-barrel domains that grip DNA in the, major groove. Both domains contact the DNA backbone. The amino-terminal, specificity domain contains a recognition loop that interacts with DNA, bases; the carboxy-terminal dimerization domain bears the site of I-kappa, B interaction. The folds of these domains are related to, immunoglobulin-like modules. The amino-terminal domain also resembles the, core domain of p53.

About this Structure

1SVC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the NF-kappa B p50 homodimer bound to DNA., Muller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC, Nature. 1995 Jan 26;373(6512):311-7. PMID:7830764

Page seeded by OCA on Mon Nov 12 19:17:49 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1svc"
Personal tools