1qox

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[[Image:1qox.gif|left|200px]]
[[Image:1qox.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1qox |SIZE=350|CAPTION= <scene name='initialview01'>1qox</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1qox", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CAA:Active+Site+(Chain+A)'>CAA</scene>, <scene name='pdbsite=CAB:Active+Site+(Chain+B)'>CAB</scene>, <scene name='pdbsite=CAC:Active+Site+(Chain+C)'>CAC</scene>, <scene name='pdbsite=CAD:Active+Site+(Chain+D)'>CAD</scene>, <scene name='pdbsite=CAE:Active+Site+(Chain+E)'>CAE</scene>, <scene name='pdbsite=CAF:Active+Site+(Chain+F)'>CAF</scene>, <scene name='pdbsite=CAG:Active+Site+(Chain+G)'>CAG</scene>, <scene name='pdbsite=CAH:Active+Site+(Chain+H)'>CAH</scene>, <scene name='pdbsite=CAI:Active+Site+(Chain+I)'>CAI</scene>, <scene name='pdbsite=CAJ:Active+Site+(Chain+J)'>CAJ</scene>, <scene name='pdbsite=CAK:Active+Site+(Chain+K)'>CAK</scene>, <scene name='pdbsite=CAL:Active+Site+(Chain+L)'>CAL</scene>, <scene name='pdbsite=CAM:Active+Site+(Chain+M)'>CAM</scene>, <scene name='pdbsite=CAN:Active+Site+(Chain+N)'>CAN</scene>, <scene name='pdbsite=CAO:Active+Site+(Chain+O)'>CAO</scene> and <scene name='pdbsite=CAP:Active+Site+(Chain+P)'>CAP</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1qox| PDB=1qox | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qox OCA], [http://www.ebi.ac.uk/pdbsum/1qox PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qox RCSB]</span>
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}}
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'''BETA-GLUCOSIDASE FROM BACILLUS CIRCULANS SP. ALKALOPHILUS'''
'''BETA-GLUCOSIDASE FROM BACILLUS CIRCULANS SP. ALKALOPHILUS'''
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[[Category: Hakulinen, N.]]
[[Category: Hakulinen, N.]]
[[Category: Rouvinen, J.]]
[[Category: Rouvinen, J.]]
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[[Category: cellulose degradation]]
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[[Category: Cellulose degradation]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:32:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:16:58 2008''
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Revision as of 03:32, 3 May 2008

Image:1qox.gif

Template:STRUCTURE 1qox

BETA-GLUCOSIDASE FROM BACILLUS CIRCULANS SP. ALKALOPHILUS


Overview

Family 1 of glycosyl hydrolases is a large and biologically important group of enzymes. A new three-dimensional structure of this family, beta-glucosidase from Bacillus circulans sp. alkalophilus is reported here. This is the first structure of beta-glucosidase from an alkaliphilic organism. The model was determined by the molecular replacement method and refined to a resolution of 2.7 A. The quaternary structure of B. circulans sp. alkalophilus beta-glucosidase is an octamer and subunits of the octamer show a similar (beta/alpha)(8) barrel fold to that previously reported for other family 1 enzymes. The crystal structure suggested that Cys169 in the active site is substituted. The Cys169 is located near the putative acid/base catalyst Glu166 and it may contribute to the high pH optimum of the enzyme. The crystal structure also revealed that the asymmetric unit contains two octamers which have a clear binding interaction with each other. The ability of the octamers to link with each other suggested that beta-glucosidase from Bacillus circulans sp. alkalophilus is able to form long polymeric assemblies, at least in the crystalline state.

About this Structure

1QOX is a Single protein structure of sequence from Bacillus circulans. Full crystallographic information is available from OCA.

Reference

The crystal structure of beta-glucosidase from Bacillus circulans sp. alkalophilus: ability to form long polymeric assemblies., Hakulinen N, Paavilainen S, Korpela T, Rouvinen J, J Struct Biol. 2000 Feb;129(1):69-79. PMID:10675298 Page seeded by OCA on Sat May 3 06:32:00 2008

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