3pyc
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='3pyc' size='340' side='right'caption='[[3pyc]], [[Resolution|resolution]] 1.96Å' scene=''> | <StructureSection load='3pyc' size='340' side='right'caption='[[3pyc]], [[Resolution|resolution]] 1.96Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3pyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3pyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PYC FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyc OCA], [https://pdbe.org/3pyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pyc RCSB], [https://www.ebi.ac.uk/pdbsum/3pyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pyc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyc OCA], [https://pdbe.org/3pyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pyc RCSB], [https://www.ebi.ac.uk/pdbsum/3pyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pyc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SMUF1_HUMAN SMUF1_HUMAN] E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.<ref>PMID:10458166</ref> <ref>PMID:19937093</ref> <ref>PMID:21402695</ref> | |
==See Also== | ==See Also== | ||
| Line 17: | Line 17: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Li | + | [[Category: Li P]] |
| - | [[Category: Li | + | [[Category: Li X]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of human SMURF1 C2 domain
| |||||||||||
